主題專刊

Inflammasomes & Innate Immunity

Inflammasome Research - From Innate to Adaptive Immunity -曜鴻生技

• Caspase-1 Detection
• Standard Antibodies
• Priming & Activation
• NLRP3 Inhibitors/Activators
• Metabolic Regulation
• Microtubule Assembly
• Inflammasome/Pyroptosis Gasdermin D & E
• Flagellin & NLRC4
• Latest Insights

Innate Immunity - Focus Toll-like Receptors (TLR) Agonists -曜鴻生技

• TLR Receptors Agonists: TLR1/TLR2; TLR3; TLR4/CD14; TLR5; TLR6/TLR12; TLR7; TLR7/8; TLR9; TLR11/12
• RIG-I-like Receptors & Cytosolic DNA Sensor Agonists: MDA5; STING
• TLR4 and TLR9 Antagonists: IAXO Compounds; iODNs
• NLRC3 – Negative Regulator of Innate Immunity

Gasdermin D Signaling & Inflammasome Research -曜鴻生技

• Gasdermin C-terminal Fragment Detection
• Gasdermin N-terminal Pore Formation Inhibition
• Inflammasome Detection
• Inflammasome Activation & Inhibition
• Inflammasome Priming

Key Inflammasome Research Tools -曜鴻生技

• Unique Antibodies: NLRP3 mAb (Cryo-2); Asc pAb; Caspase-1 (p10) mAb; Caspase-1 (p20) mAb (Casper-1)
• Potent Activators: Monosodium urate (MSU), Nigericin
• Potent Inhibitors: MCC-950; Isoliquiritigenin; 3-Hydroxybutyric acid; Arglabin and much more

Innaxon - Bringing Innate Immunity to Life -曜鴻生技

Innaxon develops and manufactures defined “Immunoceuticals” of the highest activity and purity for pre-clinical research and development applications for vaccine adjuvants and immunotherapy. Their unique biological and synthetic Toll-like Receptor (TLR) ligands (including MPLA, Lipid A, LPS and ODNs) are well-characterized and effective biological response modifiers of inappropriate or disproportionate immune responses and are provided as ready-to-use sterile solutions. Innaxon's product panel is exclusively available through AdipoGen Life Sciences.

Innaxon - Compounds powered by Lipodisq™ -曜鴻生技

Lipodisq™ are novel lipid/polymer nanoparticles that have been developed as mimics of naturally-occurring high-density lipoproteins (HDL). Innaxon's Actives in Lipodisq™ which are biosynthetic, detergent-free, water-soluble novel lipid/polymer nanoparticles with stable encapsulated active ingredients, that retain the biological activity with enhanced bioavailability.

B & T Cells Immune Regulation / Immune Checkpoints / Immuno-oncology

InVivoKines™ 2024 -曜鴻生技

InVivoKines™ are a new generation of recombinant fusion proteins for immunotherapeutic, preclinical and translational in vivo research, developed in-house by AdipoGen Life Sciences. InVivoKines™ are Fc-based fusion proteins using the Knobs-into-Holes (KIH) technology.

Quality Features of InVivoKines™ include:
• Native Conformation − Production in HEK 293 or CHO cells
• Production under Animal-Free Conditions
• High Bioactivity tested by ELISA/Cell-based Assays
• Verified Purity & Homogeneity by SEC
• Low Endotoxin Levels
• Batch-to-Batch Consistency

Immune Checkpoint Reagents: Focus on T Cells -曜鴻生技

Cancer immunotherapy (also called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving the system's natural ability to fight cancer. Immune checkpoints are regulators of the immune system. These pathways are crucial for self-tolerance, which prevents the immune system from attacking cells indiscriminately. Inhibitory checkpoint molecules, such as CTLA-4, PD-1, PD-L1 or LAG-3 are targets for cancer immunotherapy due to their potential for use in multiple types of cancers. AdipoGen Life Sciences offers a broad panel of immune checkpoint reagents, including recombinant proteins, antibodies and ELISA Kits.

TNF Superfamily - Key Cytokines in B & T cell Immuno-Regulation -曜鴻生技

TNFSF/TNFRSF together with the CD28-B7 family are two major co-signal pathways in T cell activation. CD28, ICOS, GITR, 4-1BB and OX40 pathways co-stimulate T cell activation. CTLA-4, PD-1, BTLA and CD160 pathways co-inhibit T cell activation.

Includes:

• TNFSF Overview Chart
• APRIL & BAFF, CD40-CD40L, Fas-FasL and LTβ-HVEM-LIGHT-BTLA Pathways
• TNF-α-TNF-β, CD137-CD137L and TRAIL-TRAIL-R Pathways
• OX40-OX40L, GITR-GITRL, RANK-RANKL/OPG and other TNFSF Members Pathways
• TNFSF and Cell Death Chapter
• TNF Member Reactivity Chart

Proteins with Enhanced Activity & Stability -曜鴻生技

AdipoGen Life Sciences specializes in the development of recombinant proteins that show enhanced activity and long half-life, produced in mammalian cells. Using proprietary in-house technologies together with established and published technologies, we engineer, develop and produce an innovative panel of recombinant proteins for different research fields including Cell Therapy Research.

Includes:

• TNF Ligands Multimeric Proteins
• Monomeric Interleukins (KIH-Technology)
• COMP-Proteins
• Fc-Fusion Proteins (wild-type or non-lytic)
• Proteins with Site-directed Mutations
• Proteins for Improving ex vivo T Cell Expansion and for Preclinical Research

Advanced Immune Regulation Reagents -曜鴻生技

AdipoGen Life Sciences offers a comprehensive panel of new and innovative products in the Immune Regulation Research Field. This product flyer gives an overview of unique and the newest antibodies, proteins, ELISA kits and small molecules developed by AdipoGen Life Sciences.

Autoimmune Disease Biomarkers APRIL & BAFF -曜鴻生技

• Highly Sensitive and Specific human BAFF and APRIL ELISA Kits
• Unique Blocking Antibodies for mouse BAFF and mouse APRIL
• Highly Active Multimeric Proteins
• Other Standard Antibodies for FACS and Functional Applications

Ancell Corporation - Monoclonal Antibodies Overview -曜鴻生技

Ancell's extensive panel of human CD antibodies is produced by its experienced in-house development team. The products are purified and conjugated under optimized conditions and rigorously tested in cell lines and human samples. Most of the antibodies are variously labeled to perform in multiple applications, including flow cytometry, immunohistochemistry and immunofluorescence. Several antibodies have functional applications which may be used for activation, neutralization or blocking studies.

RevMAb Biosciences - Mutant-specific Rabbit Monoclonal Antibodies -曜鴻生技

RevMAb Biosciences offers a broad panel of validated rabbit monoclonal antibodies that are specific for mutant targets and which are useful as diagnostic tools in cancer research.

RevMAb Biosciences - Histone H3 Mutation Antibodies -曜鴻生技

Histone mutations are useful diagnostic tools in cancer research. RevMAb Biosciences offers a broad panel of validated histone H3 mutations specific rabbit monoclonal antibodies.

Obesity & Metabolism

Obesity & Diabetes Research 2023 -曜鴻生技
Focus: Crucial Investment in the Future of Health

• Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research
• White & Brown Fat Cells
• Adipokines / Obesity-related ELISA Kits, Antibodies & Proteins: Adiponectin, Nampt/Visfatin, RBP4, Vaspin, ZAG
• Insulin, Isthmin-1 and GLUTs
• Obesity & Immunometabolism: Small Molecules Modulators
• IL-1 Family & Inflammasomes in Metabolic Diseases
• IL-33 & Adipose Tissue Homeostasis: Oxidation-resistant Proteins, IL-33 Blocking Antibody, ST2 Antibody for FACS
• Obesity & Angiogenesis: Potent ANG-2 Blocking Antibody
• Batokines & WAT Browning & Thermogenesis Regulators
• Myokines & Exercise - Asprosin - IL-6 - FNDC5/Irisin & FNDC4 - GDF15 & GFRAL
• AMPK Modulators, PPAR Agonists, Leptin Sensitizers, Microbiota-related Reagent, Antidiabetic Peptides

Immunometabolism Research - Focus Cell Metabolism & NAD+ Metabolism -曜鴻生技

Immunometabolism is a research field that provides new insights into the dynamic cross-talk between the immune system (immunity) and metabolic processes of an organism (metabolism).

AdipoGen Life Sciences offers a broad range of Cell Metabolism and NAD+ Metabolism Reagents:
• Small Molecules Modulators of Glycolysis, TCA Cycle, Fatty Acid Oxidation, Fatty Acid Synthesis Pathway, Amino Acid Pathways
• Inhibitors of IDO1 and Nampt
• Biologically Active Enzymes: Human Arginase I / Human IDO1 Enzyme / Mouse Nampt

Erythroferrone (human) ELISA Kit -曜鴻生技

The only Specific & Sensitive Assay on the Market!

• High Specificity
• High Sensitivity
• High Reproducibility
• Tested & Validated with many Samples
• Swiss Quality Guarantee

Neuroinflammation

Neuroscience Research -曜鴻生技

AdipoGen offers a broad range of unique tools for neuroinflammation and neurodegeneration research. This includes a broad range of Irisin-related reagents, IL-33 reagents, the best inflammasomes research reagents to study the activation of neuroinflammation, posttranslational microtubule-specific antibodies, unique progranulin ELISA Kits and proteins, a broad range of immunometabolism reagents, biologically active Netrin-1 for axon outgrowth studies, many Neurochemicals, a selected range of neuronal dyes and stain, and many other reagents.

Progranulin - Marker of Neuroinflammation -曜鴻生技

NEW mAb/mAb-based Progranulin (human) ELISA Kit
• Highly Sensitive and Specific (see Validation Poster)!
• Reliable and Cost-effective

STANDARD - Progranulin [PGRN] ELISA Kit
• Trusted Reproducible Results!
• Used to Determine Cut-Off values for FTLD!
• Cited in Hundreds of Scientific Publications!

TAG-FREE - Progranulin Recombinant Proteins
• Higher activity compared to tagged progranulins
• Suitable for in vitro and in vivo studies

Interleukin-33 -曜鴻生技
New Function of a Key Cytokine in Brain Development & Neurological Diseases

IL-33 is a nuclear-associated cytokine that is normally released by damaged or necrotic cells acting as an “alarmin”, an immediate indicator of tissue stress. IL-33 is a potent inducer of type 2 immune responses in the context of parasite infections and allergic asthma. New studies have also extended the biology of IL-33 with other functions: i) inducing brown and beige adipocyte thermogenesis and promoting insulin secretion by pancreatic islets; ii) facilitating Treg proliferation to suppress autoimmunity and to potentiate neurological recovery; and iii) exerting multiple roles in the brain.

SARS-CoV-2 / COVID-19 Research

COVID-19: Reagents for SARS-CoV-2/COVID-19 Research -曜鴻生技

• Blocking human ACE2 Antibody
• Soluble recombinant human ACE2 Protein, produced in mammalian cells (HEK 293)
• Recombinant SARS-CoV-2 RBD Domain
• ACE2 (human) ELISA Kit
• SARS-CoV-2 Neutralizing Antibodies Detection Kit
• Anti-SARS-CoV-2 Serological IgG Assay
• Anti-SARS-CoV-2 Screening Assay
• Small Molecule SARS-CoV-2 Infection Inhibitors/Modulators

Reagents for SARS-CoV-2/COVID-19 Research -曜鴻生技

Focus on:
• ACE2 (human) ELISA Kit
• SARS-CoV-2 (Spike RBD) IgG Serological ELISA Kit
• SARS-CoV-2 Neutralizing Antibodies Detection Kit
• SARS-CoV-2 Inhibitor Screening Assay
• anti-ACE2 (human), mAb (blocking) (AC384) (preservative free)
• Antiviral Compounds

ELISA Kits & Assays

ELISA Kits for Key Biomarkers - Focusing on Emerging Research Fields -曜鴻生技

AdipoGen Life Sciences offers a broad range of Biomarker Assays. This Mini-Catalog includes the standard ELISA Kits for Adiponectin | ANGPTL3 | ANGPTL6 | APRIL | BAFF | Caspase-1 | CD40L | DLK1 | GPX1 | GPX3 | IL-36β | IL-36γ | IL-36Ra | IL-37 | IL-38 | Irisin | Nampt/Visfatin | Periostin | Progranulin (new mAb/mAb) | RBP4 | Vaspin | Zinc-α Glycoprotein, and also new Assays for SARS-CoV-2 | ACE2 | ACBP | Asprosin | B7-H3 | CD40L | Erythroferrone | FGL-1 | FNDC4 | Gasdermin D & E | ICOSL | IL-1β | PD-1 and PD-L1.

The Mini-Catalog also includes the Oxidative Stress Assays from JaICA.

AdipoGen Life Sciences and JaICA ELISA Kits allow reproducible results with low inter- and intra-assay variation, show high sensitivity and can be used for a broad range of sample types.

ELISA Kits - Biomarker Assays for Preclinical & Diagnostic Research -曜鴻生技

AdipoGen Life Sciences ELISA Kits allow reproducible results with low inter- and intra-assay variation, show high sensitivity and can be used for a broad range of sample types.

Small Molecules / Biochemicals

Rare Antibiotics & Natural Products -曜鴻生技

AdipoGen Life Sciences offers a broad panel of >500 natural products, from bacterial, fungal, marine and plant sources. This panel includes known active and well-characterized natural products in combination with unusual and difficult to isolate compounds, which are unique to AdipoGen Life Sciences. All compounds are structurally determined, purified and analytically validated. Included in this panel are key standard research antibiotics, rare metabolites/antibiotics with new chemical structures (often only described once in literature and afterward lost to research), or old already forgotten substances for lead drug research, seeking new “antibiotics” with a new mode of actions and new molecular targets.

Chemodex - Fluorescent Reagents & Fine Chemicals -曜鴻生技

Chemodex is a Swiss manufacturer of:

• Common and New Fluorescent Markers, Probes, Stains, Labels
• Cellular Sensors, Ion and pH Indicators
• Reactive Oxygen Species (ROS) Detection / Nitric Oxide Detection
• Cell Biology Dyes & Probes
• Molecular Biology & Analytical Reagents
• References Compounds (Pollutant & Pesticides)
• Quorum Sensing Reagents – Largest Panel
• Specialty Reagents, APIs & Building Blocks

Modulators of Autophagy Signaling -曜鴻生技

AdipoGen Life Sciences offers a broad range of small molecules that can be used to modulate the autophagy process. This includes mTOR complex inhibitors and activators, pre-autophagosome (PAS) / initiation & nucleation modulators, autophagosome-lysosome fusion & degradation modulators and proteasome inhibitors.

Miscellaneous

Functional Antibodies -曜鴻生技
Focus: Blocking, Neutralizing, Activation & Depletion & Recombinant Antibodies

Antibodies displaying an agonist or antagonist activity (functional grade antibodies (FuncAbs™)) are powerful tools for mimicking or blocking physiological functions in vitro and in vivo. Adipogen Life Sciences offers functional grade antibodies free of preservatives and tested for low endotoxin content and useful for activation, neutralizing or blocking studies, both in vitro or in vivo. Adipogen Life Sciences also offers recombinant monoclonal antibodies (RecMAbs™) generated by antibody phage display. An important attribute of the RecMAbs™ phage display approach is the ability to design selection strategies to generate antibodies with customized functions (FuncAbs™).

The Tubulin Code: Posttranslational Modifications of Tubulin -曜鴻生技

Tubulins and microtubules (MTs) are major substrates for Posttranslational modifications (PTMs). They include tyrosination/detyrosination, D2-tubulin formation, acetylation, phosphorylation, polyamination, ubiquitination, polyglutamylation and glycylation. All are important for wound healing, neurogenesis, immune response and cancer research.

AdipoGen Life Sciences & South Bay Bio -曜鴻生技

AdipoGen Life Sciences & South Bay Bio offer a broad panel of reagents in the field of the Ubiquitin-Proteasome System (UPS).

• Highly Active Enzymes
• High Purity Proteasomes
• Cryptate-based TR-FRET Reagents
• High Active Proteasome Inhibitors
• Selective Proteasome Substrates/Probes

The Ubiquitin-Proteasome System (UPS) -曜鴻生技

The ubiquitin-proteasome system (UPS) and the autophagic-lysosomal pathway are the two major degradation systems for both native and misfolded proteins in eukaryotic cells. Proteasome inhibition has therefore implications in a number of human diseases such as cancer, inflammation and ischemic stroke and is an important therapeutic target. Adipogen Life Sciences offers a broad panel of proteasome inhibitors, modulators and fluorogenic substrates, and a panel of proteasome complex proteins and kits.

The Ubiquitin-Proteasome System (UPS) -曜鴻生技

JaICA - Unique Oxidative Stress Markers -曜鴻生技

The Japan Institute for the Control of Aging (JaICA) develops and manufactures research reagents to detect oxidative stress markers for DNA oxidation, lipid oxidation, protein oxidation and antioxidants. The monoclonal antibodies and ELISA kits detect products of oxidative damage caused by reactive oxygen species. The JaICA products are well known in the research community and cited in many scientific publications.

Notch Signaling Pathway -曜鴻生技

• Notch Receptors Notch1 & Notch2 Antibodies & Proteins
• Canonical Notch Ligands: DLL1, DLL3, DLL4, Jagged-1 and -2 Antibodies & Proteins
• Non-classical Notch Ligands: DLK1 and DLK2 Antibodies, Proteins and ELISA Kit
• Non-confirmed Notch Ligand: DNER Antibodies & Proteins
• Notch Target Hes1
• E3UBLs and DUBs
• ADAM17 Blocking Antibody
• Notch Processing/γ-Secretase Inhibitors