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與全球 Merck、Bayer、Teva 等五百家製藥廠、FDA、CIC、等等…頂尖組織長期合作。

免疫學專家~Mastering Immunity

Linda Tan博士和Nikolai Schwabe博士於2000年創立了ProImmune,"抗原特異性T細胞的偵測試劑"是ProImmune  引領全球的主力商品。提供臨床前和臨床免疫學研究的領先進階方案,包括抗原特性分析、及ELISpot和流式細胞儀技術追踪抗原特異性免疫反應的產品和服務。

關於免疫的故事…

免疫學研究不僅與疾病有關。每一種進入人體的外來物質都有可能引起免疫系統的反應。通常,這可以使我們保持無病狀態,因為可以容忍“自我”,攻擊和消除“非自我”。當“自我”被錯誤地攻擊時,我們會看到自身免疫疾病的發生,而當“非自我”佔上風時,我們就會成為急性或慢性感染的犧牲品。

從醫學研究人員到家用品牌的每個人都需要確切地知道哪些物質可以刺激免疫系統,哪些物質可以在免疫系統雷達下潛行。免疫系統可以識別的部分物質稱為抗原決定族群,而ProImmune已成為世界領先者,識別潛在的抗原決定族群並監測對其的免疫反應。

ProImmune的早期產品中有 Pro5®MHC Pentamers,用於偵測表位特異性免疫細胞,以便可以在人體血液樣本中進行分析。Pentamers以及 2016年推出的ProT2®MHC II類四聚體繼續成為ProImmune核心業務的一部分,並不斷壯大,已有超過1,600多個科研期刊文章引用了這些產品的使用。目前已經有數以千計的藥廠、生技公司和學術機構成為ProImmune的忠實客戶。

多年來,ProImmune一直積極地與其學術根源保持聯繫,並為各種合作項目做出了貢獻。公司的座右銘“掌握免疫力”反映了理解免疫系統功能的醫學重要性。

曜鴻與ProImmune的關係…

 

經過多年來曜鴻與ProImmune的愉快合作,我們為了讓台灣的研究學者享有更實在的價格與技術服務,ProImmune 決定與曜鴻正式更進一步密切合作,完成了正式簽約代理。定期執行產品教育訓練,檢討售後技術支援服務。皆為其他非正式合約經銷商(水貨商)所能比擬。

 
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歡迎來訊索取Pentamer-Handbook

ProImmune與全球500多家製藥,生物技術,臨床研究,政府和學術領域的組織合作。FDA、CIC、Merck、Bayer、Teva等等…大規模研究組織機構選擇與ProImmune合作,以解決許多行業的各種免疫學挑戰。他們很高興分享實驗的成功,並加快研究速度,研討在免疫學研究或疫苗/生物療法開發計劃中使用ProImmune的產品和服務。

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產 品

ProMix™ Peptide Pools

purified immunodominant epitope peptide pools for precise monitoring of functional T cell responses

New: SARS-Cov-2 ProMix™ Peptide Pool
 
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Figure 1. HIV-1 gag p17/p24 with three epitopes from the HIV ProMix™ peptide pool mapped to its surface.

 

Choose ProMix™, the smarter peptide pool for smart immunology

ProMix™ peptide pools from thinkpeptides consist of a select number of peptides representing the key immunodominant epitopes from a specific protein or pathogen, providing a comprehensive picture of the T cell response. Peptide selection is based on well-established and published epitopes with a wide range of HLA restrictions covering the most relevant HLA types in the population.

 

Unlike peptide pools of protein spanning overlapping peptide libraries, ProMix™ pools allow for a much greater control and purity of its constituent peptide components and avoid overloading cell cultures with large numbers of irrelevant non-responding peptides that can contribute excessive contaminants from peptide synthesis processes.

 

Key advantages of ProMixes™:

  • ProMix™ peptide pools use well characterized epitopes to provide a representative picture of the T cell response against a protein or disease.

  • Smaller numbers of peptides in each pool are designed to elicit a targeted response based on immunodominant epitopes.

  • Uniform >95% purity in pools.

  • Peptide pool content is clearly defined, allowing individual peptide responses to be mapped easily if this is required.

  • Highly efficient and cost effective method for classifying T cell response.

 

Example Published Data generated with ProMix™ Peptide Pools

Anikeeva N et al.(2016).Evaluating frequency and quality of pathogen-specific T cells

Nature Communications DOI: 10.1038/ncomms13264

Brief synopsis: Using synthetic peptides and peptide pools Anikeeva et al. have developed a Ca2+ signalling activation assay that offers new insights into the dynamics of antigen-specific T cell activation.

Screenshot-2021-08-19-at-16-13-13-Evaluating-frequency-and-quality-of-pathogen-specific-T-

Figure 1. Kinetics of calcium response of CMV-specific CD8+ T cells.CMV-specific CD8+ T cells from a healthy donor (a) and a patient after haploidentical stem cell transplantation (b) revealed different kinetics of Ca2+ signalling on antigen stimulation. CD8+ T cells were purified from PBMC by negative magnetic sorting and purified CD8 T cells were labelled with Fluo-4 and immobilized on a glass surface as described in ‘Methods’ section. The T cells from healthy donor were stimulated by CMV-derived peptide NLVPMATV at 10−4 M while the T cells from the patient were triggered with ProMix CMV peptide pool at 9 × 10−5 M. The images of responding cells are taken at 720 s after the stimulation. The data shown are representative of 5 (a) and 2 (b) independent experiments and are based on the analysis of 4,600 and 4,200 T cells, correspondingly. Scale bars, 50 μm.

Research Areas

Cancer

ProMix™                                                                         Number of peptides                     Code

ProMix™ NY-ESO-1 Peptide Pool                                                5                                   PX-NYESO

ProMix™ Prostate Specific Antigen Peptide Pool                     9                                   PX-PSA

ProMix™ Survivin Peptide Pool                                                  11                                 PX-SURV

ProMix™ bcr/c-abl Peptide Pool                                                 6                                  PX-BCR

ProMix™ Telomerase Reverse Transcriptase Peptide Pool     12                                PX-TERT

ProMix™ Prostate Specific Membrane Antigen Peptide Pool  7                                  PX-PSMA

ProMix™ gp100/p-mel Peptide Pool                                          8                                  PX-GP100

ProMix™ Tyrosinase Peptide Pool                                              6                                  PX-TYR

Infectious Diseases

ProMix™                                                                         Number of peptides                     Code

ProMix™ SARS-CoV-2 Peptide Pool – New!                              32                                 PX-COV

ProMix™ Adenovirus Peptide Pool                                             5                                   PX-ADENO

ProMix™ CMV Peptide Pool1                                                       4                                   PX-CMV

ProMix™ EBV Peptide Pool2                                                        6                                   PX-EBV

ProMix™ Influenza Peptide Pool                                                17                                  PX-FLU

ProMix™ Hepatitis C Virus Peptide Pool                                    21                                 PX-HCV

ProMix™ Hepatitis B Virus Peptide Pool                                    9                                   PX-HBV

ProMix™ HIV Peptide Pool                                                           22                                 PX-HIV

ProMix™ Human Papillomavirus Peptide Pool                         14                                 PX-HPV

ProMix™ CEFT Peptide Pool                                                       24                                 PX-CEFT

ProMix™ CEF Peptide Pool                                                         32                                 PX-CEF

ProMix™ Respiratory Syncytial Virus Peptide Pool                 28                                 PX-RSV

In most cases we aim to achieve coverage for the most common HLA types, and where applicable other alleles that may be of particular relevance with the disease or protein of interest.

 

With ProMix™ peptide pools, the pooling procedure is done for you, with the peptides guaranteed >95% pure. Each ProMix™ pool contains 25μg of each peptide and is available for dispatch within 1-2 days.

HLA-A                         HLA-B

A*01:01                       B*07:02

A*02:01                       B*08:01

A*03:01                       B*35:01

A*24:02                       B*27:05

A*11:01                       B*44:03

A*68:01                       B*57:01

                                    B*51:01

▌訂購訊息

   訂購專線:02-2668 6845 
   E-mail:yaohong@yh-bio.com.tw

   ​曜鴻生物科技有限公司