Tubulin is a major cytoskeleton component that has five distinct forms, designated α,
β, γ, δ and ε Tubulin. α and β Tubulins form heterodimers which multimerize
to form a microtubule filament. There are five β Tubulin isoforms (β1, β2, β3,
β4A and β4B) that are expressed in mammalian tissues. β1 and β4 are present
throughout the cytosol, β2 is present in the nuclei and nucleoplasm, and β3 is a
neuron-specific cytoskeletal protein. γ Tubulin forms the gammasome, which is
required for nucleating microtubule filaments at the centrosome. Both δ Tubulin and
ε Tubulin are associated with the centrosome. δ Tubulin is a homolog of the
Chlamydomonas δ Tubulin Uni3 and is found in association with the centrioles,
whereas ε Tubulin localizes to the pericentriolar material. ε Tubulin exhibits a cell
cycle-specific pattern of localization; first associating with only the older of the
centrosomes in a newly duplicated pair, and later associating with both centrosomes.
Anti-β-Tubulin mAb (HRP Conjugated) is a monoclonal anti-β-Tubulin antibody
covalently linked to horseradish prtoxidase.
