A derivative of Cyanine5 red-emitting fluorophore possessing DBCO (dibenzocyclooctyne, also known as ADIBO, azodibenzocyclooctyne) group for copper free click chemistry.
Strained cycloalkynes, such as cyclooctynes, react with azides very rapidly in the absence of copper catalyst in a strain-promoted alkyne-azide cycloaddition (SPAAC). This reaction is very fast, mild, and biocompatible.
Compared to other cycloalkynes, DBCO provide among the fastest reaction kinetics, still possessing good stability.
 
Lumiprobe 全新推出生命科學研究中最受歡迎的花青染料 —— Cyanine 系列。這些染料為 1970 年代廣泛應用於血管造影的經典花青染料吲哚菁綠（ICG）之改良版，具備更低的非特異性生物分子結合特性，並因其高消光係數及優異量子產率，展現出明亮且穩定的螢光表現。隨著 CMU 專利到期，這些高效能分子現已以更親民的價格，廣泛應用於各類生命科學領域。Cyanine 染料可用於標記多種目標，包括可溶性蛋白質、抗體、DNA 與寡核苷酸、胜肽（Peptides）及各類小分子。