AG-25B-0004V anti-CARMA1, pAb (AL220)

Polyclonal Antibody

Rabbit

N-terminal human CARMA1 (aa 1-221 containing the CARD domain).

Immunocytochemistry:(1:200)
Immunohistochemistry
Western Blot:(1:1'000)

Human
Mouse

Recognizes human and mouse CARMA1. Detects a band of ~130Dka by Western blot.

Protein A-affinity purified.

本產品短期保存請置於 4°C，長期保存建議分裝後存於 -20°C，可穩定保存至少一年，避免反覆凍融。

1. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation: O. Gaide, et al.; Nat. Immunol. 3, 836 (2002)
2. MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-κB-dependent proliferative advantage and resistance against FAS-induced cell death in B cells: L. Ho, et al.; Blood 105, 2891 (2005) 
3. Phosphorylation of the CARMA1 Linker Controls NF-κB Activation: K. Sommer, et al.; Immunity 23, 561 (2005)
4. Overexpression of Caspase Recruitment Domain (CARD) Membrane-Associated Guanylate Kinase 1 (CARMA1) and CARD9 in Primary Gastric B-Cell Lymphoma: S. Nakamura, et al.; Cancer 104, 1885 (2005)
5. Regulation of NF-kappaB activation in T cells via association of the adapter proteins ADAP and CARMA1: R.B. Medeiros, et al.; Science 316, 754 (2007)
6. Bcl10 Controls TCR- and FcγR-Induced Actin Polymerization: D. Rueda, et al.; J. Immunol. 178, 4373 (2007)
7. The proteolytic activity of the paracaspase MALT1 is key in T cell activation: F. Rebeaud, et al.; Nat. Immunol. 9, 272 (2008)
8. MAGUK-Controlled Ubiquitination of CARMA1 Modulates Lymphocyte NF-κB Activity: M.E. Moreno-Garcia, et al.; Mol. Cell Biol. 30, 922 (2010)
9. Interaction of calmodulin with Bcl10 modulates NF-κB activation: S. Edin, et al.; Mol. Immunol. 47, 2057 (2010)