AG-25B-0001V-TRIAL  25 µg
AG-25B-0001V-C100   100 µg
 
Description
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. MDA5, upon interaction with intracellular dsRNA (produced during viral replication), triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-κB, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-β and RANTES (CCL5). MDA5 is widely expressed at low levels. The expression is detected at higher levels in placenta, pancreas and spleen and barely in brain, testis and lung. Genetic variation in MDA5 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy.
 
曜鴻生技代理 AdipoGen 滿十週年，感謝支持，回饋最優惠價格！本公司提供市場中最具競爭力的報價，品質與價格兼具，是您值得信賴的首選經銷商。