AG-20B-0028-TRIAL 25 µg
AG-20B-0028-C100 100 µg
Description
TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-κB.
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AG-20B-0028 anti-TRAIL-R2 (human), mAb (TR2.21)
TRAIL Receptor 2; DR5; KILLER; TNFRSF 10B; CD262