AG-20B-0025 anti-TRAIL-R4 (human), mAb (HS402)

Monoclonal Antibody

Purified from concentrated hybridoma tissue culture supernatant.

Recombinant human TRAIL-R4 (DcR2).

Flow Cytometry
Immunocytochemistry
Immunohistochemistry: (frozen sections)
Immunoprecipitation

Human

Recognizes human TRAIL-R4. Does not cross-react with human TRAIL-R1, -R2 or -R3.

Protein G-affinity purified.

本產品短期保存請置於 4°C，長期保存建議分裝後存於 -20°C，可穩定保存至少一年，避免反覆凍融。

1. TNF-Related Apoptosis-Inducing Ligand Mediates Tumoricidal Activity of Human Monocytes Stimulated by Newcastle Disease Virus: B. Washburn, et al.; J. Immunol. 170, 1814 (2003)
2. TRAIL regulates normal erythroid maturation through an ERK-dependent pathway: P. Secchiero, et al.; Blood 103, 517 (2004)
3. Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs: T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004)
4. cFLIPL inhibits tumor necrosis factor-related apoptosis-inducing ligand-mediated NF-kappaB activation at the death-inducing signaling complex in human keratinocytes: T. Wachter, et al.; J. Biol. Chem. 279, 52824 (2004)
5. Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression: E. Contassot, et al.; Blood 111, 4780 (2008)
6. The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2: T. Hartwig, et al.; Mol. Cell 65, 730 (2017)