AG-20B-0013-TRIAL 25 µg
AG-20B-0013-C100 100 µg
Description
RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5’-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-β (Cardif) in a CARD-CARD-dependent manner resulting in NF-κB and IRF3 activation.
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AG-20B-0013 anti-MDA5 (human), mAb (Hely-1)
Helicard; Melanoma Differentiation-associated Gene 5; Interferon-induced helicase C domain-containing protein 1; IFIH1