AdipoGen Life Sciences is the "No. 1" manufacturer and supplier of inflammasome signaling research reagents. The validated high quality inflammasome research tools are used and published by the experts in inflammasome research on a daily basis.
Product Name PID Product Description
anti-Caspase-1 (p20) (mouse), mAb (Casper-1)AG-20B-0042
Recognizes endogenous full-length and activated (p20 fragment) mouse caspase-1.
anti-Caspase-1 (p10) (mouse), mAb (Casper-2)AG-20B-0044
Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1.
anti-Caspase-1 (p20) (human), mAb (Bally-1)AG-20B-0048
Recognizes endogenous full-length and activated (p20 fragment) human caspase-1.
anti-NLRP3/NALP3, mAb (Cryo-2)AG-20B-0014
Recognizes mouse and human NLRP3/NALP3.
Over 1000 Citations!
anti-Asc, pAb (AL177)AG-25B-0006
Recognizes human and mouse Asc.
anti-IL-1α (p18) (mouse), mAb (Teo-1)AG-20B-0064Recognizes full-length and cleaved p18 fragment of mouse IL-1α.anti-Caspase-8 (human), mAb (C15)AG-20B-0057Recognizes the p18 subunit of human caspase-8.anti-Caspase-8 (mouse), mAb (1G12)AG-20T-0137Recognizes full-length and the p18 cleaved fragment of mouse caspase-8.anti-Caspase-8 (mouse), mAb (3B10)AG-20T-0138Recognizes full-length and the p18 cleaved fragment of mouse caspase-8.
The Key Inflammasome Activators and Inhibitors - Including New Gasdermin Inhibitor
Product Name PIDProduct Description
Potent NLRP3 inflammasome activator.Nigericin . NaAG-CN2-0020Potent NLRP3 inflammasome activator.N-Acetyl-D-glucosamineAG-CN2-0489Acts as activator of NLRP3 inflammasome by dissociating the enzyme hexokinase from the mitochondria.Necrosulfonamide NEWAG-CR1-3705Binds directly to Gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis.U-73122 NEWAG-CR1-3698Gasdermin D N-terminal fragment (GSDMD-N)-induced pyroptosis inhibitor. Protects against GSDMD-N cytotoxicity in macrophages or against lethal infection in mice.MCC950 . Na (water soluble)AG-CR1-3615Potent and selective NLRP3 inflammasome inhibitor.IsoliquiritigeninAG-CN2-0459Inhibits NLRP3-activated Asc oligomerization. Blocks priming and activation steps.BAY 11-7082AG-CR1-0013Reduces ATPase activity of the NLRP3 inflammasome.
Prevent K+-efflux and consequently reduce Asc oligomerization and speck formation.K777 [K11777] NEWAG-CR1-0158Broad-range cathepsin inhibitor useful for inflammasome inhibition.
Priming Step of Inflammasome Activation
The most prominent function of the NLRP3 inflammasome is the processing and activation of pro-interleukin-1β (pro-IL-1β). Yet most cells do not express pro-IL-1β and thus prior expression of pro-IL-1β is required. This can be achieved by stimulating receptors such as TLRs (e.g. through LPS), Nods, TNF-Rs (e.g. through TNF-α) or IL-1R1 (through IL-1α and IL-1β) that activate NF-κB and initiate pro-IL-1β transcription. This process is called priming. Priming also induces NF-κB-dependent transcription of NLRP3.
See a Panel of ready-to-use LPS Solutions for Inflammasome Priming Activation
Do not bother anymore to solubilize your LPS, choose and use AdipoGen Life Sciences' homogenous ready-to-use LPS solutions.
- Kdo2-Lipid A (ready-to-use) (THE STANDARD)
- LPS from E. coli R515 (Re) TLRpure™ Sterile Solution (THE STANDARD)
See our Panel of TNF-α Proteins for Inflammasome Priming Activation
AdipoGen InSights - Gasdermin D Signaling & Inflammasome Research
• Gasdermin C-terminal fragment Detection • Gasdermin N-terminal Pore Formation Inhibition • Inflammasome Detection • Inflamamsome Activation & Inhibition • Inflammasome Priming