Cat. # AG-CN2-0031
Synonyms：LAT-B; NSC 339663
Merck Index：14: 5378
Source/Host Chemicals：Isolated from Latrunculia magnifica.
Purity Chemicals：≥98% (HPLC)
Appearance：White to light yellow solid.
Solubility：Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).
Identity：Determined by 1H-NMR.
Shipping and Handling
Short Term Storage：+4°C
Long Term Storage：-20°C
Handling Advice：Protect from light.
Use/Stability：Stable for at least 2 years after receipt when stored at -20°C.
- Cell permeable marine toxin .
- Disrupts microfilament-mediated processes .
- Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin [1, 2, 3].
- Depolymerizes actin filaments (F-actin) .
- Less potent than Latrunculin A (Prod. No. AG-CN2-0027). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies [4, 5].
- Acts via a different mechanism than cytochalasins.
- Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983)
- Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166, 191 (1986)
- Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213, 316 (1987)
- Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13, 127 (1989)
- Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114, 1025 (2001)
- RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens: T. Miki, et al.; Plant Cell Physiol. 56, 737 (2015)
- Evidence that an unconventional actin can provide essential F-actin function and that a surveillance system monitors F-actin integrity in Chlamydomonas: M. Onishi, et al.; Genetics 202, 977 (2016)