Cat. # AG-CN2-0031

Product Details

Synonyms:LAT-B; NSC 339663

Product Type:Chemical

Properties

Formula:C20H29NO5S

MW:395.5

Merck Index:14: 5378

CAS:76343-94-7

Source/Host Chemicals:Isolated from Latrunculia magnifica.

Purity Chemicals:≥98% (HPLC)

Appearance:White to light yellow solid.

Solubility:Soluble in DMSO (25mg/ml) or ethanol (25mg/ml).

Identity:Determined by 1H-NMR.

InChi Key:NSHPHXHGRHSMIK-JRIKCGFMSA-N

Shipping and Handling

Shipping:AMBIENT

Short Term Storage:+4°C

Long Term Storage:-20°C

Handling Advice:Protect from light.

Use/Stability:Stable for at least 2 years after receipt when stored at -20°C.

Latrunculin B

    • Cell permeable marine toxin [1].
    • Disrupts microfilament-mediated processes [2].
    • Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin [1, 2, 3].
    • Depolymerizes actin filaments (F-actin) [3].
    • Less potent than Latrunculin A (Prod. No. AG-CN2-0027). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies [4, 5].
    • Acts via a different mechanism than cytochalasins.

    Product References

    1. Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983)
    2. Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166, 191 (1986)
    3. Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213, 316 (1987)
    4. Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13, 127 (1989)
    5. Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114, 1025 (2001)
    6. RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens: T. Miki, et al.; Plant Cell Physiol. 56, 737 (2015)
    7. Evidence that an unconventional actin can provide essential F-actin function and that a surveillance system monitors F-actin integrity in Chlamydomonas: M. Onishi, et al.; Genetics 202, 977 (2016)

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