Cat. # AG-CR1-0159
Synonyms：3-(4-Fluorophenyl)-chroman-4-one
Product Type：Chemical
Properties
Formula：C15H11FO2
MW：242.2
CAS：1143863-69-7
Purity Chemicals：≥98% (HPLC)
Appearance：White to off-white solid.
Solubility：Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.
Identity：Determined by 1H-NMR.
InChi Key：XKAFGKFIJBGYAP-UHFFFAOYSA-N
Smiles：O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31
Shipping and Handling
Shipping：AMBIENT
Short Term Storage：+4°C
Long Term Storage：-20°C
Handling Advice：Keep cool and dry.
Use/Stability：Stable for at least 2 years after receipt when stored at -20°C.
KBU2046
- Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
- Does not bind to Cdc37 or HSP90β alone.
- Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
- Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
Product References
- Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)