Cat. # AG-CR1-0159
Synonyms:3-(4-Fluorophenyl)-chroman-4-one
Product Type:Chemical
Properties
Formula:C15H11FO2
MW:242.2
CAS:1143863-69-7
Purity Chemicals:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.
Identity:Determined by 1H-NMR.
InChi Key:XKAFGKFIJBGYAP-UHFFFAOYSA-N
Smiles:O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31
Shipping and Handling
Shipping:AMBIENT
Short Term Storage:+4°C
Long Term Storage:-20°C
Handling Advice:Keep cool and dry.
Use/Stability:Stable for at least 2 years after receipt when stored at -20°C.
KBU2046
- Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
- Does not bind to Cdc37 or HSP90β alone.
- Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
- Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.
Product References
- Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)