KBU2046

Cat. # AG-CR1-0159

Synonyms:3-(4-Fluorophenyl)-chroman-4-one

Product Type:Chemical

Properties

Formula:C15H11FO2

MW:242.2

CAS:1143863-69-7

Purity Chemicals:≥98% (HPLC)

Appearance:White to off-white solid.

Solubility:Soluble in DMSO, ethanol, methanol or DCM. Insoluble in water.

Identity:Determined by 1H-NMR.

InChi Key:XKAFGKFIJBGYAP-UHFFFAOYSA-N

Smiles:O=C1C(C2=CC=C(F)C=C2)COC3=CC=CC=C31

Shipping and Handling

Shipping:AMBIENT

Short Term Storage:+4°C

Long Term Storage:-20°C

Handling Advice:Keep cool and dry.

Use/Stability:Stable for at least 2 years after receipt when stored at -20°C.

KBU2046

    • Highly selective metastasis inhibitor in vitro. Binds to and stabilizes Cdc37-HSP90β heterocomplexes, consequently blocking its function and inhibiting cancer cell motility.
    • Does not bind to Cdc37 or HSP90β alone.
    • Inhibits cancer metastasis in vivo in murine models of human prostate and breast cancer.
    • Shown to exhibit a complete lack of cellular cytotoxicity and systemic toxicity.

    Product References

    1. Precision therapeutic targeting of human cancer cell motility: L. Xu, et al.; Nat. Commun. 9, 2454 (2018)
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