Cat. # CHI-MF-110BTNL2
More Information | |
Product Details | |
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Synonyms | Butyrophilin-like Protein 2 |
Product Type | Protein |
Properties | |
Source/Host | CHO cells |
Sequence | The extracellular domain of mouse BTNL2 (aa 26-457) is fused to the N-terminus of the Fc region of mouse IgG2a. |
Crossreactivity | Mouse |
Biological Activity | A butyrophilin-like molecule that functions to inhibit T cell activation. |
Purity | ≥98% (SDS-PAGE) |
Endotoxin Content | <0.06EU/μg protein (LAL test; Lonza). |
Reconstitution | Reconstitute at 100μg/ml in sterile PBS. |
Formulation | Lyophilized from 0.2μm-filtered solution in PBS. |
Other Product Data | NCBI reference NP_524574.1: BTNL2 (mouse) |
Declaration | Manufactured by Chimerigen. |
Shipping and Handling | |
Shipping | BLUE ICE |
Short Term Storage | +4°C |
Long Term Storage | -20°C |
Handling Advice | Avoid freeze/thaw cycles. |
Use/Stability | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
BTNL2 (mouse):Fc (mouse) (rec.)
Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-κB and AP-1 signaling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.